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Fortamet is a prescription biguanide available in multiple countries including the United States. It was
first marketed in 2004. It is available in an Oral Tablet, extended release. It contains
one active ingredient: <a href="https://go.drugbank.com/drugs/DB00331">Metformin</a>, in its salt form Metformin hydrochloride. <a href="https://go.drugbank.com/drugs/DB00331">Metformin</a> is a
medication used with diet and exercise to control blood sugar in diabetes and is sometimes
used to control high blood sugar in a disease called polycystic ovary syndrome (or PCOS).
Norvasc is a prescription dihydropyridine calcium channel blocker available in multiple countries including
the United States, Canada, and Italy. It was first marketed in 1992. It is available in an
Oral Tablet. It contains one active ingredient: <a href="https://go.drugbank.com/drugs/DB00381">Amlodipine</a>, in its salt form Amlodipine
besylate. <a href="https://go.drugbank.com/drugs/DB00381">Amlodipine</a> is a heart medication used to treat high blood pressure and chest
pain caused by heart disease.
Prilosec is a prescription and over-the-counter proton pump inhibitor available
in multiple countries including the United States and Canada. It was first marketed in 1990. It is available in an Oral
Capsule, delayed release, an Oral Granule, delayed release, and an Oral Tablet, delayed
release. It contains one active ingredient: <a href="https://go.drugbank.com/drugs/DB00338">Omeprazole</a>, in its salt form Omeprazole
magnesium. <a href="https://go.drugbank.com/drugs/DB00338">Omeprazole</a> is a medication used to improve the symptoms of heartburn, and to
treat related conditions such as ulcers, tissue damage and infection with the bacteria
called H. pylori.
Truvada is a prescription HIV nucleoside analog reverse transcriptase inhibitor
(HIV NRTI) available in multiple countries including the United States, Canada, Italy, and the EU. It was first marketed
in 2004. It is available in an Oral Tablet, film-coated, an Oral Tablet, coated, and an Oral
Tablet. It contains two active ingredients: <a href="https://go.drugbank.com/drugs/DB00879">Emtricitabine</a> and <a href="https://go.drugbank.com/drugs/DB00300">Tenofovir disoproxil</a>, in its
salt form Tenofovir disoproxil fumarate. <a href="https://go.drugbank.com/drugs/DB00879">Emtricitabine</a> is a medication used to treat and
prevent HIV. <a href="https://go.drugbank.com/drugs/DB00300">Tenofovir disoproxil</a> is a medication used to treat hepatitis B infection and to
manage HIV infection.
Zocor is a prescription HMG CoA-reductase inhibitor available in multiple countries including the United
States, Canada, and Italy. It was first marketed in 1990. It is available in an Oral Tablet
and an Oral Tablet, film-coated. It contains one active ingredient: <a href="https://go.drugbank.com/drugs/DB00641">Simvastatin</a>.
<a href="https://go.drugbank.com/drugs/DB00641">Simvastatin</a> is a medication used to treat high cholesterol and reduce the risk of
cardiovascular disease including heart attacks and stroke.
Humira is a prescription tumor necrosis factor (TNF) blocker available in multiple countries including the
United States, Canada, the EU, Italy, and Indonesia. It was first marketed in 2002. It is
available in a Subcutaneous Injection. It contains one active ingredient: <a href="https://go.drugbank.com/drugs/DB00051">Adalimumab</a>.
<a href="https://go.drugbank.com/drugs/DB00051">Adalimumab</a> is a medication used to treat a wide variety of inflammatory conditions such as
rheumatoid arthritis, Crohn's disease, and ankylosing spondylitis.
Herceptin is a prescription HER2 receptor antagonist available in multiple countries including the United
States, Canada, the EU, Italy, and Indonesia. It was first marketed in 1998. It is
available in an Intravenous Injection and a Subcutaneous Injection. It contains one
active ingredient: <a href="https://go.drugbank.com/drugs/DB00072">Trastuzumab</a>. <a href="https://go.drugbank.com/drugs/DB00072">Trastuzumab</a> is an injectable medication used to treat
certain types of cancers that overexpress the HER2 protein.
Flonase is an over-the-counter corticosteroid available in multiple countries including the United States and
Canada. It was first marketed in 1993. It is available in a Nasal Spray, metered. It
contains one active ingredient: <a href="https://go.drugbank.com/drugs/DB00588">Fluticasone propionate</a>. <a href="https://go.drugbank.com/drugs/DB00588">Fluticasone propionate</a> is a
medication used to treat asthma, certain skin conditions, and a runny nose.
Plan-B is an over-the-counter progestin available in multiple countries including the United States and
Canada. It was first marketed in 1999. It is available in an Oral Tablet. It contains one
active ingredient: <a href="https://go.drugbank.com/drugs/DB00367">Levonorgestrel</a>. <a href="https://go.drugbank.com/drugs/DB00367">Levonorgestrel</a> is a hormone used in birth control
medications and at higher doses as an emergency birth control pill for up to 72 hours
following sexual intercourse.
Imodium is an over-the-counter opioid agonist available in multiple countries including the United States,
Canada, Germany, Colombia, Italy, and Indonesia. It was first marketed in 1983. It is
available in an Oral Capsule, an Oral Tablet, and an Oral Solution. It contains one active
ingredient: <a href="https://go.drugbank.com/drugs/DB00836">Loperamide</a>, in its salt form Loperamide hydrochloride. <a href="https://go.drugbank.com/drugs/DB00836">Loperamide</a> is a
medication used to treat diarrhea.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends on an RNA-dependent RNA polymerase (RdRp) enzyme complex for genomic replication, which can be inhibited by a class of drugs known as nucleoside analogues. Remdesivir (GS-5734) is an adenosine triphosphate analogue first described in the literature in 2016 as a potential treatment for Ebola.[A191379, A222393] Broad antiviral activity of remdesivir is suggested by its mechanism of action, and to date, it has demonstrated in vitro activity against the Arenaviridae, Flaviviridae, Filoviridae, Paramyxoviridae, Pneumoviridae, and Coronaviridae viral families. Remdesivir activity against the Coronaviridae family was first demonstrated in 2017, leading to considerable interest in remdesivir as a possible treatment for COVID-19.[A191427, A198810] Remdesivir was confirmed as a non-obligate chain terminator of RdRp from SARS-CoV-2 and the related SARS-CoV and MERS-CoV, and has been investigated in multiple COVID-19 clinical trials.[L12174, L12177]
Based on aggregate data, remdesivir was granted an FDA Emergency Use Authorization (EUA) on May 1st, 2020. The FDA subsequently granted full approval for remdesivir as a COVID-19 treatment on October 22, 2020, while simultaneously updating the EUA to cover those patients not included under the approved indication. Remdesivir is currently marketed under the trademark name VEKLURY® by Gilead Sciences Inc. Remdesivir in combination with baricitinib for the treatment of COVID-19, was granted an FDA Emergency Use Authorization on 19 Novermber 2020.
We've put together a COVID-19 Information Dashboard, to provide a comprehensive summary of relevant COVID-19 research, in an effort to help researchers find the information they need quickly and effectively.
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DrugBank Online is offered to the public as a free-to-access resource. Use and re-distribution of the content of DrugBank Online or the DrugBank Data, in whole or in part, for any purpose requires a license. Academic users may apply for a free license for certain use cases and all other users require a paid license.
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2017 Nov 8. doi: 10.1093/nar/gkx1037.
Law V, Knox C, Djoumbou Y, Jewison T, Guo AC, Liu Y, Maciejewski A, Arndt D, Wilson M, Neveu V, Tang A, Gabriel G, Ly C, Adamjee S, Dame ZT, Han B, Zhou Y, Wishart DS. DrugBank 4.0: shedding new light on drug metabolism. Nucleic Acids Res. 2014 Jan 1;42(1):D1091-7.
Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
Wishart DS, Knox C, Guo AC, Shrivastava S, Hassanali M, Stothard P, Chang Z, Woolsey J. DrugBank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D668-72.