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Please visit the COVID-19 & Cancer Resource Center where COVID-related content is freely available.
- Research Briefs | Open AccessCarino Gurjao, Rong Zhong, Koichiro Haruki, Yvonne Y. Li, Liam F. Spurr, Henry Lee-Six, Brendan Reardon, Tomotaka Ugai, Xuehong Zhang, Andrew D. Cherniack, Mingyang Song, Eliezer M. Van Allen, Jeffrey A. Meyerhardt, Jonathan A. Nowak, Edward L. Giovannucci, Charles S. Fuchs, Kana Wu, Shuji Ogino and Marios GiannakisCancer Discov October 1 2021 11 (10) 2446-2455; DOI:10.1158/2159-8290.CD-20-1656
Whole-exome sequencing of colorectal cancer samples collected from participants in large prospective cohort studies revealed an association between an alkylating mutational signature and red meat intake.
- Research ArticlesOtto Metzger Filho, Giuseppe Viale, Shayna Stein, Lorenzo Trippa, Denise A. Yardley, Ingrid A. Mayer, Vandana G. Abramson, Carlos L. Arteaga, Laura M. Spring, Adrienne G. Waks, Eileen Wrabel, Michelle K. DeMeo, Aditya Bardia, Patrizia Dell'Orto, Leila Russo, Tari A. King, Kornelia Polyak, Franziska Michor, Eric P. Winer and Ian E. KropCancer Discov October 1 2021 11 (10) 2474-2487; DOI:10.1158/2159-8290.CD-20-1557
HER2 heterogeneity was identified as a strong predictor of resistance to neoadjuvant HER2-targeted therapy in a prospective phase II clinical trial of patients with HER2-positive breast cancer.
- Research Articles | AuthorChoiceSadegh Saghafinia, Krisztian Homicsko, Annunziata Di Domenico, Stephan Wullschleger, Aurel Perren, Ilaria Marinoni, Giovanni Ciriello, Iacovos P. Michael and Douglas HanahanCancer Discov October 1 2021 11 (10) 2638-2657; DOI:10.1158/2159-8290.CD-20-1637
Multiomics profiling reveals dedifferentiation along a development lineage is a discrete step during pancreatic neuroendocrine tumor progression, orchestrated by upregulating microRNA-181 and the transcription factor HMGB3.
- ReviewsLisa Derosa, Bertrand Routy, Antoine Desilets, Romain Daillère, Safae Terrisse, Guido Kroemer and Laurence ZitvogelCancer Discov October 1 2021 11 (10) 2396-2412; DOI:10.1158/2159-8290.CD-21-0236
- ReviewsReece J. Knippel, Julia L. Drewes and Cynthia L. SearsCancer Discov October 1 2021 11 (10) 2378-2395; DOI:10.1158/2159-8290.CD-21-0324
- ReviewsMarie J. Parsons, Tuomas Tammela and Lukas E. DowCancer Discov October 1 2021 11 (10) 2413-2429; DOI:10.1158/2159-8290.CD-21-0190
- ReviewCatherine B. Meador, Lecia V. Sequist and Zofia PiotrowskaCancer Discov September 1 2021 11 (9) 2145-2157; DOI:10.1158/2159-8290.CD-21-0226
News from Cancer Discovery
- Free Article | Cancer Therapy Doesn't Diminish Vaccine Efficacy
Patients with hematologic malignancies, however, less likely to get effective protection from COVID-19 shot. - Free Article | NIH Director Will Leave Lasting Mark on Cancer
Researchers praise Francis Collins's emphasis on large-scale science projects. - Free Article | COVID-19 Use Causes Tocilizumab Shortage
Limited supply of IL6 inhibitor poses challenges for treating cytokine release syndrome.
OnlineFirst Research Articles & Briefs
- Mis-splicing of GNAS by mutant SRSF2 and U2AF1 drives MDSEmily C Wheeler, et al.
- ZRSR2 sex bias in pDCs and BPDCNKatsuhiro Togami, et al.
- Reusable Kids Sticker Book, Learning Toys for Boys Girls, DinoZhixin Qiu, et al.
- Spatial Heterogeneity of Brain TumorsMaximilian O Schaettler, et al.
- Prioritize AML dependencies via in vivo CRISPR screenShan Lin, et al.
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- Repurposing vandetanib plus everolimus for the treatment of ACVR1-mutant diffuse intrinsic pontine gliomaLast mentioned on Thu Oct 07 2021
- Igor Kid's Topo Ski Synthetic Snow BootLast mentioned on Fri Sep 17 2021
- Mobocertinib (TAK-788): A Targeted Inhibitor of EGFR Exon 20 Insertion Mutants in Non–Small Cell Lung CancerLast mentioned on Mon Sep 20 2021
- Integrative RNA-omics discovers GNAS alternative splicing as a phenotypic driver of splicing factor-mutant neoplasmsLast mentioned on Sun Oct 10 2021
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